The enhancer analyzes all assemblies referenced by the current project. If an assembly with persistent classes has been detected (or if a project reference exists) the assembly is listed as reference in the NDO project file. You can choose, which assemblies should be analyzed by the enhancer.
To analyze the assemblies using Reflection, they must be loaded into an AppDomain of the enhancer. The enhancer is based on the .NET Framework, so your assemblies can support .NET Standard up to version 2.0. .NET Standard 2.1 assemblies cannot be loaded by any version of the .NET Framework.